IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase
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چکیده
منابع مشابه
Histological and Clinical Characteristics of Patients with Chronic Hepatitis C and Persistently Normal Alanine Aminotransferase Levels
Patients with chronic hepatitis C virus (HCV) infection and persistently normal alanine aminotransferase (PNALT) are generally described to have mild liver disease. The aim of this study was to compare clinical and histological features in HCV-infected patients with PNALT and elevated ALT. Patients presenting to the University of Illinois Medical Center, Chicago, who had biopsy proven HCV, an A...
متن کاملClinical Features of Hepatitis C Virus Carriers With Persistently Normal Alanine Aminotransferase Levels
Hepatitis C virus (HCV) infection causes chronic hepatitis, which frequently leads to hepatic fibrosis and hepatocellular carcinoma (HCC). Alanine aminotransferase (ALT) is a biomarker of hepatocyte injury and is associated with the progression of hepatic fibrosis. Advanced hepatic fibrosis also predisposes HCV carriers to a risk of HCC. In contrast, some cases with persistent HCV infection hav...
متن کاملclinical features of hepatitis c virus carriers with persistently normal alanine aminotransferase levels
hepatitis c virus (hcv) infection causes chronic hepatitis, which frequently leads to hepatic fibrosis and hepatocellular carcinoma (hcc). alanine aminotransferase (alt) is a biomarker of hepatocyte injury and is associated with the progression of hepatic fibrosis. advanced hepatic fibrosis also predisposes hcv carriers to a risk of hcc. in contrast, some cases with persistent hcv infection hav...
متن کاملHistological features and HLA class II alleles in hepatitis C virus chronically infected patients with persistently normal alanine aminotransferase levels.
OBJECTIVE A significant proportion of individuals with chronic hepatitis C virus (HCV) infection have persistently normal alanine aminotransferase (ALT) levels. Although data are controversial, such patients usually have weaker histological damage and a lower progression rate of fibrosis. The aims of this study were: (1) to compare demographic, virological, and histological parameters of HCV pa...
متن کاملChronic infection with hepatitis C virus in patients with elevated or persistently normal serum alanine aminotransferase levels: comparison of hepatic histology and response to interferon therapy.
Ninety-five patients with chronic hepatitis C virus (HCV) infection, 35 with persistently normal serum alanine aminotransferase (ALT) levels, were randomized to treatment with daily interferon (IFN) for 3 months, followed by IFN 3 times weekly (TIW) for 12 months (group A) or TIW for 18 months (group B). Patients with elevated versus normal ALT levels had similar demographic and virologic chara...
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ژورنال
عنوان ژورنال: World Journal of Hepatology
سال: 2013
ISSN: 1948-5182
DOI: 10.4254/wjh.v5.i11.635